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Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues
Using single-cell sequence analysis, we discovered that a high proportion of cells in tissues as diverse as buccal epithelium and heart muscle contain high proportions of clonal mutant mtDNA expanded from single initial mutant mtDNA molecules. We demonstrate that intracellular clonal expansion of so...
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| Главные авторы: | , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2002
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC122802/ https://ncbi.nlm.nih.gov/pubmed/11943860 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.072670199 |
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