Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues

Using single-cell sequence analysis, we discovered that a high proportion of cells in tissues as diverse as buccal epithelium and heart muscle contain high proportions of clonal mutant mtDNA expanded from single initial mutant mtDNA molecules. We demonstrate that intracellular clonal expansion of so...

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Detalhes bibliográficos
Main Authors: Nekhaeva, Ekaterina, Bodyak, Natalya D., Kraytsberg, Yevgenya, McGrath, Sean B., Van Orsouw, Nathalie J., Pluzhnikov, Anna, Wei, Jeanne Y., Vijg, Jan, Khrapko, Konstantin
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2002
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC122802/
https://ncbi.nlm.nih.gov/pubmed/11943860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.072670199
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