Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues

Using single-cell sequence analysis, we discovered that a high proportion of cells in tissues as diverse as buccal epithelium and heart muscle contain high proportions of clonal mutant mtDNA expanded from single initial mutant mtDNA molecules. We demonstrate that intracellular clonal expansion of so...

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Bibliografiska uppgifter
Huvudupphovsmän: Nekhaeva, Ekaterina, Bodyak, Natalya D., Kraytsberg, Yevgenya, McGrath, Sean B., Van Orsouw, Nathalie J., Pluzhnikov, Anna, Wei, Jeanne Y., Vijg, Jan, Khrapko, Konstantin
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2002
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC122802/
https://ncbi.nlm.nih.gov/pubmed/11943860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.072670199
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