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Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNA

8-oxoguanine (8-oxoG), ring-opened purines (formamidopyrimidines or Fapys), and other oxidized DNA base lesions generated by reactive oxygen species are often mutagenic and toxic, and have been implicated in the etiology of many diseases, including cancer, and in aging. Repair of these lesions in al...

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Veröffentlicht in:Proc Natl Acad Sci U S A
Hauptverfasser: Hazra, Tapas K., Izumi, Tadahide, Boldogh, Istvan, Imhoff, Barry, Kow, Yoke W., Jaruga, Pawel, Dizdaroglu, Miral, Mitra, Sankar
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2002
Schlagworte:
Biological Sciences
Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122556/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11904416/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.062053799
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