Stimulation of human 8-oxoguanine-DNA glycosylase by AP-endonuclease: potential coordination of the initial steps in base excision repair

8-Oxoguanine-DNA glycosylase 1 (OGG1), with intrinsic AP lyase activity, is the major enzyme for repairing 7,8-dihydro-8-oxoguanine (8-oxoG), a critical mutagenic DNA lesion induced by reactive oxygen species. Human OGG1 excised the damaged base from an 8-oxoG·C-containing duplex oligo with a very l...

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Detalhes bibliográficos

Publicado no:	Nucleic Acids Res
Principais autores:	Hill, Jeff W., Hazra, Tapas K., Izumi, Tadahide, Mitra, Sankar
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Oxford University Press 2001
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC29662/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11139613/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/29.2.430
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