Stimulation of human 8-oxoguanine-DNA glycosylase by AP-endonuclease: potential coordination of the initial steps in base excision repair

8-Oxoguanine-DNA glycosylase 1 (OGG1), with intrinsic AP lyase activity, is the major enzyme for repairing 7,8-dihydro-8-oxoguanine (8-oxoG), a critical mutagenic DNA lesion induced by reactive oxygen species. Human OGG1 excised the damaged base from an 8-oxoG·C-containing duplex oligo with a very l...

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Bibliografiska uppgifter

I publikationen:	Nucleic Acids Res
Huvudupphov:	Hill, Jeff W., Hazra, Tapas K., Izumi, Tadahide, Mitra, Sankar
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Oxford University Press 2001
Ämnen:	Article
Länkar:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC29662/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11139613/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/29.2.430
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