Essential role of p38γ in K-Ras transformation independent of phosphorylation

MAPK cascades play the critical role in regulating Ras oncogene activity by phosphorylation-dependent mechanisms. Whereas the ERK MAPK pathway is required for Ras transformation, our previous works established that the p38 activity is inhibitory to Ras signaling in both experimental and ras-mutated...

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Bibliographic Details
Main Authors: Tang, Jun, Qi, Xiaomei, Mercola, Dan, Han, Jiahuai, Chen, Guan
Format: Artigo
Language:Inglês
Published: 2005
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1224721/
https://ncbi.nlm.nih.gov/pubmed/15851477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M500699200
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