Residue 182 influences the second step of protein-tyrosine phosphatase-mediated catalysis.

Previous enzyme kinetic and structural studies have revealed a critical role for Asp181 (PTP1B numbering) in PTP (protein-tyrosine phosphatase)-mediated catalysis. In the E-P (phosphoenzyme) formation step, Asp181 functions as a general acid, while in the E-P hydrolysis step it acts as a general bas...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Pedersen, Anja K, Guo, Xiao-Ling, Møller, Karin B, Peters, Günther H, Andersen, Henrik S, Kastrup, Jette S, Mortensen, Steen B, Iversen, Lars F, Zhang, Zhong-Yin, Møller, Niels Peter H
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223950/
https://ncbi.nlm.nih.gov/pubmed/14572311
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20030565
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados