Visualization of intermediate and transition-state structures in protein-tyrosine phosphatase catalysis.

Engineering site-specific amino acid substitutions into the protein-tyrosine phosphatase (PTPase) PTP1 and the dual-specific vaccinia H1-related phosphatase (VHR), has kinetically isolated the two chemical steps of the reaction and provided a rare opportunity for examining transition states and dire...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Denu, J M, Lohse, D L, Vijayalakshmi, J, Saper, M A, Dixon, J E
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC39825/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8637902/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.6.2493
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