A catalytic mechanism for the dual-specific phosphatases.

Dual-specific protein-tyrosine phosphatases have the common active-site sequence motif HCXXGXXRS(T). The role of the conserved hydroxyl was investigated by changing serine-131 to an alanine (S131A) in the dual-specific protein-tyrosine phosphatase VHR. The pH profile of the kcat/Km value for the S13...

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Argitaratua izan da:	Proc Natl Acad Sci U S A
Egile Nagusiak:	Denu, J M, Dixon, J E
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	National Academy of Sciences 1995
Gaiak:	Research Article
Sarrera elektronikoa:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41611/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7597052/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.13.5910
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