Amplification–mutagenesis: Evidence that “directed” adaptive mutation and general hypermutability result from growth with a selected gene amplification

When a particular lac mutant of Escherichia coli starves in the presence of lactose, nongrowing cells appear to direct mutations preferentially to sites that allow growth (adaptive mutation). This observation suggested that growth limitation stimulates mutability. Evidence is provided here that this...

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Bibliographic Details
Main Authors: Hendrickson, Heather, Slechta, E. Susan, Bergthorsson, Ulfar, Andersson, Dan I., Roth, John R.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences 2002
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC122336/
https://ncbi.nlm.nih.gov/pubmed/11830643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.032680899
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