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Amplification–mutagenesis: Evidence that “directed” adaptive mutation and general hypermutability result from growth with a selected gene amplification

When a particular lac mutant of Escherichia coli starves in the presence of lactose, nongrowing cells appear to direct mutations preferentially to sites that allow growth (adaptive mutation). This observation suggested that growth limitation stimulates mutability. Evidence is provided here that this...

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Bibliografiske detaljer
Main Authors: Hendrickson, Heather, Slechta, E. Susan, Bergthorsson, Ulfar, Andersson, Dan I., Roth, John R.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2002
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC122336/
https://ncbi.nlm.nih.gov/pubmed/11830643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.032680899
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