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Amplification–mutagenesis: Evidence that “directed” adaptive mutation and general hypermutability result from growth with a selected gene amplification

When a particular lac mutant of Escherichia coli starves in the presence of lactose, nongrowing cells appear to direct mutations preferentially to sites that allow growth (adaptive mutation). This observation suggested that growth limitation stimulates mutability. Evidence is provided here that this...

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Detalhes bibliográficos
Main Authors: Hendrickson, Heather, Slechta, E. Susan, Bergthorsson, Ulfar, Andersson, Dan I., Roth, John R.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2002
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC122336/
https://ncbi.nlm.nih.gov/pubmed/11830643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.032680899
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