Amplification–mutagenesis: Evidence that “directed” adaptive mutation and general hypermutability result from growth with a selected gene amplification

When a particular lac mutant of Escherichia coli starves in the presence of lactose, nongrowing cells appear to direct mutations preferentially to sites that allow growth (adaptive mutation). This observation suggested that growth limitation stimulates mutability. Evidence is provided here that this...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Hendrickson, Heather, Slechta, E. Susan, Bergthorsson, Ulfar, Andersson, Dan I., Roth, John R.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2002
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122336/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11830643/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.032680899
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