Identification by site-directed mutagenesis of amino acids contributing to ligand-binding specificity or signal transduction properties of the human FP prostanoid receptor.

Prostanoid receptors belong to the class of heptahelical plasma membrane receptors. For the five prostanoids, eight receptor subtypes have been identified. They display an overall sequence similarity of roughly 30%. Based on sequence comparison, single amino acids in different subtypes of different...

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Bibliographic Details
Main Authors: Neuschäfer-Rube, Frank, Engemaier, Eva, Koch, Sina, Böer, Ulrike, Püschel, Gerhard P
Format: Artigo
Language:Inglês
Published: 2003
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223288/
https://ncbi.nlm.nih.gov/pubmed/12519077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20021429
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