Substrate specificity of the metalloproteinase pregnancy-associated plasma protein-A (PAPP-A) assessed by mutagenesis and analysis of synthetic peptides: substrate residues distant from the scissile bond are critical for proteolysis.

Human pregnancy-associated plasma protein-A (PAPP-A) cleaves insulin-like growth factor (IGF) binding protein-4 (IGFBP-4), causing a dramatic reduction in its affinity for IGF-I and -II. Through this mechanism, PAPP-A is a regulator of IGF bioactivity in several systems, including the human ovary an...

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Main Authors: Laursen, Lisbeth S, Overgaard, Michael T, Nielsen, Claus G, Boldt, Henning B, Hopmann, Kathrin H, Conover, Cheryl A, Sottrup-Jensen, Lars, Giudice, Linda C, Oxvig, Claus
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222882/
https://ncbi.nlm.nih.gov/pubmed/12241545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20020831
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