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Targeting protein inactivation through an oligomerization chain reaction

A general strategy for inactivation of target proteins is presented, which we have termed “oligomerization chain reaction.” This technique is based on the fusion of the self-associating coiled-coil (CC) domain of the nuclear factor promyelocytic leukemia (PML) to target proteins that are able to sel...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Contegno, Francesco, Cioce, Mario, Pelicci, Pier Giuseppe, Minucci, Saverio
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122285/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11842196/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.042460299
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