The ETO Protein Disrupted in t(8;21)-Associated Acute Myeloid Leukemia Is a Corepressor for the Promyelocytic Leukemia Zinc Finger Protein

The ETO protein was originally identified by its fusion to the AML-1 transcription factor in translocation (8;21) associated with the M2 form of acute myeloid leukemia (AML). The resulting AML-1–ETO fusion is an aberrant transcriptional regulator due to the ability of ETO, which does not bind DNA it...

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Main Authors: Melnick, Ari M., Westendorf, Jennifer J., Polinger, Adam, Carlile, Graeme W., Arai, Sally, Ball, Helen J., Lutterbach, Bart, Hiebert, Scott W., Licht, Jonathan D.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2000
Teme:
Transcriptional Regulation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC110824/
https://ncbi.nlm.nih.gov/pubmed/10688654
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