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Crystal structure of the stimulatory complex of GTP cyclohydrolase I and its feedback regulatory protein GFRP

In the presence of phenylalanine, GTP cyclohydrolase I feedback regulatory protein (GFRP) forms a stimulatory 360-kDa complex with GTP cyclohydrolase I (GTPCHI), which is the rate-limiting enzyme in the biosynthesis of tetrahydrobiopterin. The crystal structure of the stimulatory complex reveals tha...

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Detalhes bibliográficos
Main Authors: Maita, Nobuo, Okada, Kengo, Hatakeyama, Kazuyuki, Hakoshima, Toshio
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC122169/
https://ncbi.nlm.nih.gov/pubmed/11818540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.022646999
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