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Crystal structure of the stimulatory complex of GTP cyclohydrolase I and its feedback regulatory protein GFRP
In the presence of phenylalanine, GTP cyclohydrolase I feedback regulatory protein (GFRP) forms a stimulatory 360-kDa complex with GTP cyclohydrolase I (GTPCHI), which is the rate-limiting enzyme in the biosynthesis of tetrahydrobiopterin. The crystal structure of the stimulatory complex reveals tha...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The National Academy of Sciences
2002
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC122169/ https://ncbi.nlm.nih.gov/pubmed/11818540 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.022646999 |
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