GTP Cyclohydrolase I Expression, Protein, and Activity Determine Intracellular Tetrahydrobiopterin Levels, Independent of GTP Cyclohydrolase Feedback Regulatory Protein Expression

GTP cyclohydrolase I (GTPCH) is a key enzyme in the synthesis of tetrahydrobiopterin (BH4), a required cofactor for nitricoxide synthases and aromatic amino acid hydroxylases. Alterations of GTPCH activity and BH4 availability play an important role in human disease. GTPCH expression is regulated by...

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Autores principales: Tatham, Amy L., Crabtree, Mark J., Warrick, Nicholas, Cai, Shijie, Alp, Nicholas J., Channon, Keith M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2009
Materias:
Enzyme Catalysis and Regulation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2679467/
https://ncbi.nlm.nih.gov/pubmed/19286659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807959200
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