Overexpression of GTP Cyclohydrolase 1 Feedback Regulatory Protein Is Protective in a Murine Model of Septic Shock

Overproduction of nitric oxide (NO) by inducible NO synthase contributes toward refractory hypotension, impaired microvascular perfusion, and end-organ damage in septic shock patients. Tetrahydrobiopterin (BH(4)) is an essential NOS cofactor. GTP cyclohydrolase 1 (GCH1) is the rate-limiting enzyme f...

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Publicado en:Shock
Autores principales: Starr, Anna, Sand, Claire A., Heikal, Lamia, Kelly, Peter D., Spina, Domenico, Crabtree, Mark, Channon, Keith M., Leiper, James M., Nandi, Manasi
Formato: Artigo
Lenguaje:Inglês
Publicado: Lippincott Williams & Wilkins 2014
Materias:
Basic Science Aspects
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4851220/
https://ncbi.nlm.nih.gov/pubmed/25046538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/SHK.0000000000000235
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