Validating the GTP-cyclohydrolase 1-feedback regulatory complex as a therapeutic target using biophysical and in vivo approaches

BACKGROUND AND PURPOSE: 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (BH(4)) is an essential cofactor for nitric oxide biosynthesis. Substantial clinical evidence indicates that intravenous BH(4) restores vascular function in patients. Unfortunately, oral BH(4) has limited efficacy. Therefore, orally bi...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Hussein, D, Starr, A, Heikal, L, McNeill, E, Channon, K M, Brown, P R, Sutton, B J, McDonnell, J M, Nandi, M
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley & Sons, Ltd 2015
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4543619/
https://ncbi.nlm.nih.gov/pubmed/26014146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13202
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