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Validating the GTP-cyclohydrolase 1-feedback regulatory complex as a therapeutic target using biophysical and in vivo approaches
BACKGROUND AND PURPOSE: 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (BH(4)) is an essential cofactor for nitric oxide biosynthesis. Substantial clinical evidence indicates that intravenous BH(4) restores vascular function in patients. Unfortunately, oral BH(4) has limited efficacy. Therefore, orally bi...
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| Publicado no: | Br J Pharmacol |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley & Sons, Ltd
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4543619/ https://ncbi.nlm.nih.gov/pubmed/26014146 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13202 |
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