Validating the GTP-cyclohydrolase 1-feedback regulatory complex as a therapeutic target using biophysical and in vivo approaches

BACKGROUND AND PURPOSE: 6R-L-erythro-5,6,7,8-tetrahydrobiopterin (BH(4)) is an essential cofactor for nitric oxide biosynthesis. Substantial clinical evidence indicates that intravenous BH(4) restores vascular function in patients. Unfortunately, oral BH(4) has limited efficacy. Therefore, orally bi...

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Bibliografische gegevens
Gepubliceerd in:Br J Pharmacol
Hoofdauteurs: Hussein, D, Starr, A, Heikal, L, McNeill, E, Channon, K M, Brown, P R, Sutton, B J, McDonnell, J M, Nandi, M
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley & Sons, Ltd 2015
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Research Papers
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4543619/
https://ncbi.nlm.nih.gov/pubmed/26014146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13202
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