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The N-terminal Peptide of Mammalian GTP Cyclohydrolase I Is an Autoinhibitory Control Element and Contributes to Binding the Allosteric Regulatory Protein GFRP
GTP cyclohydrolase I (GTPCH) is the rate-limiting enzyme for biosynthesis of tetrahydrobiopterin (BH(4)), an obligate cofactor for NO synthases and aromatic amino acid hydroxylases. BH(4) can limit its own synthesis by triggering decameric GTPCH to assemble in an inhibitory complex with two GTPCH fe...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3069394/ https://ncbi.nlm.nih.gov/pubmed/21163945 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.196204 |
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