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The N-terminal Peptide of Mammalian GTP Cyclohydrolase I Is an Autoinhibitory Control Element and Contributes to Binding the Allosteric Regulatory Protein GFRP

GTP cyclohydrolase I (GTPCH) is the rate-limiting enzyme for biosynthesis of tetrahydrobiopterin (BH(4)), an obligate cofactor for NO synthases and aromatic amino acid hydroxylases. BH(4) can limit its own synthesis by triggering decameric GTPCH to assemble in an inhibitory complex with two GTPCH fe...

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Main Authors: Higgins, Christina E., Gross, Steven S.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2011
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069394/
https://ncbi.nlm.nih.gov/pubmed/21163945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.196204
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