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The N-terminal Peptide of Mammalian GTP Cyclohydrolase I Is an Autoinhibitory Control Element and Contributes to Binding the Allosteric Regulatory Protein GFRP

GTP cyclohydrolase I (GTPCH) is the rate-limiting enzyme for biosynthesis of tetrahydrobiopterin (BH(4)), an obligate cofactor for NO synthases and aromatic amino acid hydroxylases. BH(4) can limit its own synthesis by triggering decameric GTPCH to assemble in an inhibitory complex with two GTPCH fe...

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Bibliografiske detaljer
Main Authors: Higgins, Christina E., Gross, Steven S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069394/
https://ncbi.nlm.nih.gov/pubmed/21163945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.196204
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