In vivo studies of the gamma subunit of retinal cGMP-phophodiesterase with a substitution of tyrosine-84.

The inhibitory rod cGMP phosphodiesterase gamma subunit (PDEgamma) is a major component of the photoresponse and is required to support rod integrity. Pdeg(tm1)/Pdeg(tm1) mice (which lack PDEgamma owing to a targeted disruption of the Pdeg gene) suffer from a very rapid and severe photoreceptor dege...

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Detalhes bibliográficos
Main Authors: Tsang, S H, Yamashita, C K, Doi, K, Salchow, D J, Bouvier, N, Mendelsohn, M, Gouras, P, Farber, D B, Goff, S P
Formato: Artigo
Idioma:Inglês
Publicado em: 2001
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1221591/
https://ncbi.nlm.nih.gov/pubmed/11171042
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