Akt, a Target of Phosphatidylinositol 3-Kinase, Inhibits Apoptosis in a Differentiating Neuronal Cell Line

Phosphatidylinositol (PI) 3-kinase has been suggested to mediate cell survival. Consistent with this possibility, apoptosis of conditionally (simian virus 40 T(ts)) immortalized rat hippocampal H19-7 neuronal cells was increased in response to wortmannin, an inhibitor of PI 3-kinase. Downstream effe...

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Bibliographic Details
Main Authors: Eves, Eva M., Xiong, Wen, Bellacosa, Alfonso, Kennedy, Scott G., Tsichlis, Philip N., Rosner, Marsha Rich, Hay, Nissim
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 1998
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC121450/
https://ncbi.nlm.nih.gov/pubmed/9528786
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