Tcl1 enhances Akt kinase activity and mediates its nuclear translocation

The TCL1 oncogene at 14q32.1 is involved in the development of human mature T-cell leukemia. The mechanism of action of Tcl1 is unknown. Because the virus containing the v-akt oncogene causes T-cell lymphoma in mice and Akt is a key player in transduction of antiapoptotic and proliferative signals i...

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Hoofdauteurs: Pekarsky, Yuri, Koval, Anatoliy, Hallas, Cora, Bichi, Roberta, Tresini, Maria, Malstrom, Scott, Russo, Giandomenico, Tsichlis, Philip, Croce, Carlo M.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The National Academy of Sciences 2000
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC16186/
https://ncbi.nlm.nih.gov/pubmed/10716693
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