Tcl1 enhances Akt kinase activity and mediates its nuclear translocation

The TCL1 oncogene at 14q32.1 is involved in the development of human mature T-cell leukemia. The mechanism of action of Tcl1 is unknown. Because the virus containing the v-akt oncogene causes T-cell lymphoma in mice and Akt is a key player in transduction of antiapoptotic and proliferative signals i...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Pekarsky, Yuri, Koval, Anatoliy, Hallas, Cora, Bichi, Roberta, Tresini, Maria, Malstrom, Scott, Russo, Giandomenico, Tsichlis, Philip, Croce, Carlo M.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 2000
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC16186/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10716693/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.040557697
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