Covalent stabilization of coiled coils of the HIV gp41 N region yields extremely potent and broad inhibitors of viral infection

Peptides from the N-heptad repeat region of the HIV gp41 protein can inhibit viral fusion, but their potency is limited by a low tendency to form a trimeric coiled-coil. Accordingly, stabilization of N peptides by fusion with the stable coiled-coil IZ yields nanomolar inhibitors [Eckert, D. M. &...

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Main Authors: Bianchi, Elisabetta, Finotto, Marco, Ingallinella, Paolo, Hrin, Renee, Carella, Anthony V., Hou, Xiaoli S., Schleif, William A., Miller, Michael D., Geleziunas, Romas, Pessi, Antonello
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2005
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1200264/
https://ncbi.nlm.nih.gov/pubmed/16129831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0502449102
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