CD8α-Deficient Mice Are Highly Susceptible to 5-Fluorouracil-Induced Lethality

Intestinal intraepithelial lymphocytes (i-IEL) expressing CD8α are located in the intestine and may confer protection against invasion of intestinal microflora. We found that mice rendered deficient in CD8α molecules by homologous recombination were susceptible to 5-fluorouracil (5-FU)-induced letha...

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Autori principali: Itoh, Naoto, Nishimura, Hitoshi, Matsuguchi, Tetsuya, Yajima, Toshiki, Mokuno, Yasuji, Hiromatsu, Takashi, Nimura, Yuji, Yoshikai, Yasunobu
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2002
Soggetti:
Cellular Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC119987/
https://ncbi.nlm.nih.gov/pubmed/11986258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CDLI.9.3.550-557.2002
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