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CD8α-Deficient Mice Are Highly Susceptible to 5-Fluorouracil-Induced Lethality

Intestinal intraepithelial lymphocytes (i-IEL) expressing CD8α are located in the intestine and may confer protection against invasion of intestinal microflora. We found that mice rendered deficient in CD8α molecules by homologous recombination were susceptible to 5-fluorouracil (5-FU)-induced letha...

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Detalhes bibliográficos
Main Authors: Itoh, Naoto, Nishimura, Hitoshi, Matsuguchi, Tetsuya, Yajima, Toshiki, Mokuno, Yasuji, Hiromatsu, Takashi, Nimura, Yuji, Yoshikai, Yasunobu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC119987/
https://ncbi.nlm.nih.gov/pubmed/11986258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CDLI.9.3.550-557.2002
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