Highly Potent Inhibition of Human Immunodeficiency Virus Type 1 Replication by TAK-220, an Orally Bioavailable Small-Molecule CCR5 Antagonist

TAK-220 is a member of a novel class of chemokine receptor antagonists and is highly specific to CCR5, as determined by receptor binding and calcium mobilization assays. The compound selectively inhibited coreceptor-mediated entry of human immunodeficiency virus type 1 (HIV-1) into host cells and HI...

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Detalhes bibliográficos
Main Authors: Takashima, Katsunori, Miyake, Hiroshi, Kanzaki, Naoyuki, Tagawa, Yoshihiko, Wang, Xin, Sugihara, Yoshihiro, Iizawa, Yuji, Baba, Masanori
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1196284/
https://ncbi.nlm.nih.gov/pubmed/16048963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.8.3474-3482.2005
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