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Isolation and Characterization of Human Immunodeficiency Virus Type 1 Resistant to the Small-Molecule CCR5 Antagonist TAK-652

TAK-652, a novel small-molecule chemokine receptor antagonist, is a highly potent and selective inhibitor of CCR5-using (R5) human immunodeficiency virus type 1 (HIV-1) replication in vitro. Since TAK-652 is orally bioavailable and has favorable pharmacokinetic profiles in humans, it is considered a...

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Detalhes bibliográficos
Main Authors: Baba, Masanori, Miyake, Hiroshi, Wang, Xin, Okamoto, Mika, Takashima, Katsunori
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1797735/
https://ncbi.nlm.nih.gov/pubmed/17116673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01079-06
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