TAK-220, a Novel Small-Molecule CCR5 Antagonist, Has Favorable Anti-Human Immunodeficiency Virus Interactions with Other Antiretrovirals In Vitro

TAK-220 is a CCR5 antagonist, part of the new class of anti-human immunodeficiency virus type 1 (anti-HIV-1) entry inhibitors. We evaluated the anti-HIV-1 interactions between TAK-220 and various antiretrovirals in vitro. Synergy was observed with all drugs at the 90 and 95% inhibitory concentration...

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Detalhes bibliográficos
Main Authors: Tremblay, Cécile L., Giguel, Françoise, Guan, Yongbiao, Chou, Ting-Chao, Takashima, Katsunori, Hirsch, Martin S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1196290/
https://ncbi.nlm.nih.gov/pubmed/16048964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.8.3483-3485.2005
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