Analysis of Binding Sites for the New Small-Molecule CCR5 Antagonist TAK-220 on Human CCR5

G protein-coupled receptor CCR5 is the main coreceptor for macrophage-tropic human immunodeficiency virus type 1 (HIV-1), and various small-molecule CCR5 antagonists are being developed to treat HIV-1 infection. It has been reported that such CCR5 antagonists, including TAK-779, bind to a putative b...

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Detalhes bibliográficos
Main Authors: Nishikawa, Masao, Takashima, Katsunori, Nishi, Toshiya, Furuta, Rika A., Kanzaki, Naoyuki, Yamamoto, Yoshio, Fujisawa, Jun-ichi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1280122/
https://ncbi.nlm.nih.gov/pubmed/16251315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.49.11.4708-4715.2005
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