Disruption of Murine Mus81 Increases Genomic Instability and DNA Damage Sensitivity but Does Not Promote Tumorigenesis

The Mus81-Eme1 endonuclease is implicated in the efficient rescue of broken replication forks in Saccharomyces cerevisiae and Schizosaccharomyces pombe. We have used gene targeting to study the function of the Mus81-Eme1 endonuclease in mammalian cells. Mus81-deficient mice develop normally and are...

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Bibliographische Detailangaben
Hauptverfasser: Dendouga, Najoua, Gao, Hui, Moechars, Dieder, Janicot, Michel, Vialard, Jorge, McGowan, Clare H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2005
Schlagworte:
Chromosome Structure and Dynamics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1190297/
https://ncbi.nlm.nih.gov/pubmed/16107704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.25.17.7569-7579.2005
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