A role for transferrin receptor in triggering apoptosis when targeted with gambogic acid

Transferrin receptor (TfR) has been shown to be significantly overexpressed in different types of cancers. We discovered TfR as a target for gambogic acid (GA), used in traditional Chinese medicine and a previously undiscovered link between TfR and the rapid activation of apoptosis. The binding site...

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Detalhes bibliográficos
Main Authors: Kasibhatla, Shailaja, Jessen, Katayoun A., Maliartchouk, Sergei, Wang, Jean Yu, English, Nicole M., Drewe, John, Qiu, Ling, Archer, Shannon P., Ponce, Anthony E., Sirisoma, Nilantha, Jiang, Songchun, Zhang, Han-Zhong, Gehlsen, Kurt R., Cai, Sui Xiong, Green, Douglas R., Tseng, Ben
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1189297/
https://ncbi.nlm.nih.gov/pubmed/16103367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0406731102
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