A role for transferrin receptor in triggering apoptosis when targeted with gambogic acid

Transferrin receptor (TfR) has been shown to be significantly overexpressed in different types of cancers. We discovered TfR as a target for gambogic acid (GA), used in traditional Chinese medicine and a previously undiscovered link between TfR and the rapid activation of apoptosis. The binding site...

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Detaylı Bibliyografya
Asıl Yazarlar: Kasibhatla, Shailaja, Jessen, Katayoun A., Maliartchouk, Sergei, Wang, Jean Yu, English, Nicole M., Drewe, John, Qiu, Ling, Archer, Shannon P., Ponce, Anthony E., Sirisoma, Nilantha, Jiang, Songchun, Zhang, Han-Zhong, Gehlsen, Kurt R., Cai, Sui Xiong, Green, Douglas R., Tseng, Ben
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2005
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1189297/
https://ncbi.nlm.nih.gov/pubmed/16103367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0406731102
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