Discovery of substituted N′-(2-oxoindolin-3-ylidene)benzohydrazides as new apoptosis inducers using a cell- and caspase-based HTS assay

We report the discovery of a series of substituted N′-(2-oxoindolin-3-ylidene)benzohydrazides as inducers of apoptosis using our proprietary cell- and caspase-based ASAP HTS assay. Through SAR studies, N′-(4-bromo-5-methyl-2-oxoindolin-3-ylidene)-3,4,5-trimethoxybenzohydrazide (3g) was identified as...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Sirisoma, Nilantha, Pervin, Azra, Drewe, John, Tseng, Ben, Cai, Sui Xiong
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Ltd. 2009
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7126024/
https://ncbi.nlm.nih.gov/pubmed/19369076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2009.03.121
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