MX1013, a dipeptide caspase inhibitor with potent in vivo antiapoptotic activity

1. Caspases play a critical role in apoptosis, and are considered to be key targets for the design of cytoprotective drugs. As part of our antiapoptotic drug-discovery effort, we have synthesized and characterized Z-VD-fmk, MX1013, as a potent, irreversible dipeptide caspase inhibitor. 2. MX1013 inh...

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Detalhes bibliográficos
Main Authors: Yang, Wu, Guastella, John, Huang, Jin-Cheng, Wang, Yan, Zhang, Li, Xue, Dong, Tran, Minhtam, Woodward, Richard, Kasibhatla, Shailaja, Tseng, Ben, Drewe, John, Cai, Sui Xiong
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
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Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1574042/
https://ncbi.nlm.nih.gov/pubmed/12970077
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjp.0705450
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