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Deubiquitinating function of ataxin-3: Insights from the solution structure of the Josephin domain
Spinocerebellar ataxia type 3 is a human neurodegenerative disease resulting from polyglutamine tract expansion. The affected protein, ataxin-3, which contains an N-terminal Josephin domain followed by tandem ubiquitin (Ub)-interacting motifs (UIMs) and a polyglutamine stretch, has been implicated i...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2005
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1188261/ https://ncbi.nlm.nih.gov/pubmed/16118278 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0506344102 |
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