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Deubiquitinating function of ataxin-3: Insights from the solution structure of the Josephin domain

Spinocerebellar ataxia type 3 is a human neurodegenerative disease resulting from polyglutamine tract expansion. The affected protein, ataxin-3, which contains an N-terminal Josephin domain followed by tandem ubiquitin (Ub)-interacting motifs (UIMs) and a polyglutamine stretch, has been implicated i...

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Detalhes bibliográficos
Main Authors: Mao, Yuxin, Senic-Matuglia, Francesca, Di Fiore, Pier Paolo, Polo, Simona, Hodsdon, Michael E., De Camilli, Pietro
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1188261/
https://ncbi.nlm.nih.gov/pubmed/16118278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0506344102
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