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Deubiquitinating function of ataxin-3: Insights from the solution structure of the Josephin domain
Spinocerebellar ataxia type 3 is a human neurodegenerative disease resulting from polyglutamine tract expansion. The affected protein, ataxin-3, which contains an N-terminal Josephin domain followed by tandem ubiquitin (Ub)-interacting motifs (UIMs) and a polyglutamine stretch, has been implicated i...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2005
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1188261/ https://ncbi.nlm.nih.gov/pubmed/16118278 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0506344102 |
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