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Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic Wee1 via multiple pathways
At the onset of M phase, the activity of somatic Wee1 (Wee1A), the inhibitory kinase for cyclin-dependent kinase (CDK), is down-regulated primarily through proteasome-dependent degradation after ubiquitination by the E3 ubiquitin ligase SCF(β-TrCP). The F-box protein β-TrCP (β-transducin repeat-cont...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
National Academy of Sciences
2005
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1187955/ https://ncbi.nlm.nih.gov/pubmed/16085715 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0500410102 |
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