Cyclin-dependent kinase (CDK) phosphorylation destabilizes somatic Wee1 via multiple pathways

At the onset of M phase, the activity of somatic Wee1 (Wee1A), the inhibitory kinase for cyclin-dependent kinase (CDK), is down-regulated primarily through proteasome-dependent degradation after ubiquitination by the E3 ubiquitin ligase SCF(β-TrCP). The F-box protein β-TrCP (β-transducin repeat-cont...

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Detaylı Bibliyografya
Asıl Yazarlar: Watanabe, Nobumoto, Arai, Harumi, Iwasaki, Jun-ichi, Shiina, Masaaki, Ogata, Kazuhiro, Hunter, Tony, Osada, Hiroyuki
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2005
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1187955/
https://ncbi.nlm.nih.gov/pubmed/16085715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0500410102
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