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A Bifunctional Regulatory Element in Human Somatic Wee1 Mediates Cyclin A/Cdk2 Binding and Crm1-Dependent Nuclear Export

Sophisticated models for the regulation of mitotic entry are lacking for human cells. Inactivating human cyclin A/Cdk2 complexes through diverse approaches delays mitotic entry and promotes inhibitory phosphorylation of Cdk1 on tyrosine 15, a modification performed by Wee1. We show here that cyclin...

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Detalhes bibliográficos
Main Authors: Li, Changqing, Andrake, Mark, Dunbrack, Roland, Enders, Greg H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798281/
https://ncbi.nlm.nih.gov/pubmed/19858290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01876-08
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