Control of liver cell fate decision by a gradient of TGFβ signaling modulated by Onecut transcription factors

During liver development, hepatocytes and biliary cells differentiate from common progenitors called hepatoblasts. The factors that control hepatoblast fate decision are unknown. Here we report that a gradient of activin/TGFβ signaling controls hepatoblast differentiation. High activin/TGFβ signalin...

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Detalhes bibliográficos
Main Authors: Clotman, Frédéric, Jacquemin, Patrick, Plumb-Rudewiez, Nicolas, Pierreux, Christophe E., Van der Smissen, Patrick, Dietz, Harry C., Courtoy, Pierre J., Rousseau, Guy G., Lemaigre, Frédéric P.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2005
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1186184/
https://ncbi.nlm.nih.gov/pubmed/16103213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.340305
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