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Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation

The FOXO family of forkhead transcription factors plays a key role in a variety of biological processes, including metabolism, cell proliferation, and oxidative stress response. We previously reported that Foxo1, a member of the FOXO family, is regulated through reversible acetylation catalyzed by h...

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Bibliographic Details
Main Authors: Matsuzaki, Hitomi, Daitoku, Hiroaki, Hatta, Mitsutoki, Aoyama, Hisanori, Yoshimochi, Kenji, Fukamizu, Akiyoshi
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2005
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1183558/
https://ncbi.nlm.nih.gov/pubmed/16076959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0502738102
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