Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity

Longevity regulatory genes include the Forkhead transcription factor FOXO and the NAD-dependent histone deacetylase silent information regulator 2 (Sir2). Genetic studies demonstrate that Sir2 acts to extend lifespan in Caenorhabditis elegans upstream of DAF-16, a member of the FOXO family, in the i...

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Bibliografiska uppgifter
Huvudupphovsmän: Daitoku, Hiroaki, Hatta, Mitsutoki, Matsuzaki, Hitomi, Aratani, Satoko, Ohshima, Takayuki, Miyagishi, Makoto, Nakajima, Toshihiro, Fukamizu, Akiyoshi
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2004
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC454161/
https://ncbi.nlm.nih.gov/pubmed/15220471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0400593101
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