The LXXLL motif of murine forkhead transcription factor FoxO1 mediates Sirt1-dependent transcriptional activity

The forkhead transcription factor FoxO1 has been identified as a negative regulator of insulin/IGF-1 signaling. Its function is inhibited by phosphorylation and nuclear exclusion through a PI3K-dependent pathway. However, the structure/function relationship of FoxO1 has not been elucidated completel...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Nakae, Jun, Cao, Yongheng, Daitoku, Hiroaki, Fukamizu, Akiyoshi, Ogawa, Wataru, Yano, Yoshihiko, Hayashi, Yoshitake
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2006
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1550275/
https://ncbi.nlm.nih.gov/pubmed/16917544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI25518
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