Chemobiosynthesis of Novel 6-Deoxyerythronolide B Analogues by Mutation of the Loading Module of 6-Deoxyerythronolide B Synthase 1

Chemobiosynthesis (J. R. Jacobsen, C. R. Hutchinson, D. E. Cane, and C. Khosla, Science 277:367-369, 1997) is an important route for the production of polyketide analogues and has been used extensively for the production of analogues of 6-deoxyerythronolide B (6-dEB). Here we describe a new route fo...

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Autors principals: Murli, Sumati, MacMillan, Karen S., Hu, Zhihao, Ashley, Gary W., Dong, Steven D., Kealey, James T., Reeves, Christopher D., Kennedy, Jonathan
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2005
Matèries:
Physiology and Biotechnology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1183267/
https://ncbi.nlm.nih.gov/pubmed/16085842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.71.8.4503-4509.2005
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